Effect of tumor-infiltrating lymphocytes depending on the presence of postmastectomy radiotherapy on the prognosis in pT1-2N1M0 breast cancer

Background Currently, it remains unclear regarding the association between tumor-infiltrating lymphocytes (TILs) and efficacy of postoperative radiotherapy in primary tumors. Here we attempted to investigate effect TILs depending on presence postmastectomy (PMRT) prognosis pT1-2N1M0 breast cancer. Methods The clinical data cancer patients undergoing mastectomy axillary lymph node dissection were retrospectively analyzed. was assessed based infiltration degree (low: ≤10%, high: >10%), then with low high analyzed or absence PMRT. Results Totally 213 eligible for study, including 162 cases 51 infiltration. High-infiltration tended be ER/PR-negative, HER2-positive, have histological grade. triple-negative HER2-positive subtypes higher compared Luminal A subtype. Regarding local-regional recurrence-free survival, overall survival (OS) rates, differences all inapparent whether high- low-infiltration high-infiltration with/without Compared those without PMRT, PMRT showed a significantly increased OS rate (92.8% vs. 80.0%, p =0.023). Multivariate analysis further confirmed as an independent predicator (HR: 0.228, 95%CI: 0.081-0.644, =0.005). Conclusion High may associated clinicopathological factors. Low-infiltration patients, but not derive benefits from